Smooth muscle cell (SMC) proliferation and migration is considered to play a major role in the development of intimal hyperplasia, an early stage in the progression of atherosclerosis and restenosis. The underlying mechanism of the development of the formation of intimal hyperplasia is still under investigation. With regard to the involvement of calcium in cellular processes such as proliferation and migration, the effects of calcium channel blockers (CCBs) in the development of atherosclerosis have always been deemed a subject worthy of investigation. This brief review will discuss the effects of CCBs in intimal hyperplasia.
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