Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 10  Issue 1
Ischemia-related neuronal death in SHRSP
Yasuko Sakurai-Yamashita, Kimihiro Yamashita, Masami Niwa
Pages: 53 - 57
Number of pages: 5
Current Topics in Pharmacology
Volume 10  Issue 1

Copyright © 2006 Research Trends. All rights reserved


Delayed neuronal death of the pyramidal neurons in the CA1 subfield of the hippocampus was observed in stroke-prone spontaneously hypertensive rats, SHRSP, when the bilateral common carotid arteries were occluded for 10 min. To elucidate the mechanism of the neuronal death produced only by the occlusion of the carotid arteries, the vulnerability of SHRSP to ischemic insult, we have been studying the substances expressed by glial cells and the permeability of blood-brain barriers. In this review we described in detail about the expression of monocyte chemoattractant protein-1 (MCP-1) after 2 vessel-occlusion to clarify the involvement of the infiltration of blood monocytes in the mechanism of the neuronal death. MCP-1 mRNA was clearly expressed in the molecular layer of the dentate gyrus at 1 day after the ischemia-reperfusion and in the entire CA1 subfield at 2 days after 2 vessel-occlusion. Most of the cells expressing MCP-1 were astrocytes. The concentration of MCP-1 protein dramatically increased in the hippocampus at 2 days after 2 vessel-occlusion. Taken together with the findings of our previous study showing an increased permeability of the blood-brain barrier in the hippocampus from 12 h after ischemia-reperfusion, the astrocytes expressing MCP-1 might therefore induce the migration of monocytes into the brain parenchyma. As a result, such astrocytes expressing MCP-1 may therefore be related to the pathological events of delayed neuronal death in the pyramidal neurons.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms