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Current Topics in Pharmacology   Volumes    Volume 10  Issue 1
Recent progress in clinical application of noscapine: a review
M. Mahmoudian
Pages: 81 - 86
Number of pages: 6
Current Topics in Pharmacology
Volume 10  Issue 1

Copyright © 2006 Research Trends. All rights reserved


Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, this drug is devoid of any significant analgesic, sedative or euphoriant associated with this group of drugs. While this is an old chemical, the only important clinical effect associated with noscapine is its antitussive activity. However, recent study has shown that this compound can antagonize the effect of bradykinin. Considering the biological role of bradykinin, this has resulted in elucidation of various pharmacological effect for noscapine; such as suppression of ACE-induced cough response. This has been resulted in its application in prevention of cough side effect of useful anti-hypertensive agents such as captopril and enalpril. Also, it has been shown that noscapine, via inhibition of bradykinin, reduces brain edema in the prenatal rats. This has been resulted in its application as an effective drug in reducing mortality after stroke. Similarly, it has been shown that noscapine can inhibit tumor growth with little toxicity to normal tissues or inhibition of immune responses. It has been suggested that noscapine interfere with microtubules and induces apoptosis. This drug can reverse sensitivity of paclitaxel resistant human ovarian cancer cells. It is concluded that noscapine has great potential as a new drug.

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