Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 11  Issue 1
Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus
Takahiko Shiina, Yasutake Shimizu, Ammar Boudaka, Jürgen Wörl, Winfried L. Neuhuber, Tadashi Takewaki
Pages: 11 - 17
Number of pages: 7
Current Topics in Pharmacology
Volume 11  Issue 1

Copyright © 2007 Research Trends. All rights reserved

The enteric nervous system plays a vital role in gastrointestinal smooth muscle motility. Unlike the tunica muscularis of the stomach, small intestine and large intestine, which is constituted entirely of smooth muscles, the external muscle layers of the mammalian esophagus contain striated muscle fibers. These striated muscle fibers are innervated exclusively by excitatory vagal efferents and terminate on motor endplates. It is believed that peristalsis in the striated esophageal muscle is executed according to a sequence preprogrammed in a medullary swallowing network and modulated via vago-vagal reflexes.  By contrast, the presence of a distinct ganglionated myenteric plexus in the striated muscle portion of the mammalian esophagus has long been known. However, the role of the intrinsic nervous system in the peristalsis of the striated muscle portion of the esophagus has remained enigmatic, and has been neglected in terms of peristaltic control.  Recently, the regulatory roles of intrinsic neurons in the esophageal striated muscle have been investigated. The esophageal intrinsic neurons may compose a ‘local neural reflex pathway’ and regulate the motility of the striated muscle via influencing the neurotransmission in the motor endplate.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms