Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 11  Issue 1
The pharmacology of cyclo-oxygenase-2 products of mammalian endocannabinoids
D. F. Woodward, Y. Liang, J. W. Wang, R. M. Burk, Achim H-P. Krauss
Pages: 71 - 80
Number of pages: 10
Current Topics in Pharmacology
Volume 11  Issue 1

Copyright © 2007 Research Trends. All rights reserved

Cyclo-oxygenase-2 (COX-2) inhibitors have proved to be highly effective therapy for rheumatoid arthritis and, arguably, advantageous compared to traditional non-steroidal anti-inflammatory drugs (NSAIDS). The inducible nature of COX-2 has been proposed as an explanation for the high clinical efficacy of COX-2 inhibitors in inflammatory diseases. More recently, the mammalian endo-cannabinoids have been demonstrated as substrates for COX-2 but not COX-1. The resultant neutral prostaglandin (PG) biosynthetic products appear to be pharmacologically unique. Specifically, prostaglandin F-ethanolamide (prostamide F) and prostaglandin E2-glyceryl ester (PGE2-glyceryl ester) have been the subject of recent pharmacological investigation and their effects appear unrelated to interaction with known prostanoid receptors. It is possible that attenuated neutral PG formation may contribute to the beneficial effects of COX-2 inhibitors. This will be determined by future research. In terms of current therapeutics, a prostamide F analog has already been approved for treating glaucoma and is extremely effective. Further therapeutic applications may be identified as the biology of neutral prostanoids is gradually elucidated.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms