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Current Topics in Biochemical Research   Volumes    Volume 12  Issue 1
Abstract
Synuclein proteins and their roles as metal binding proteins
Xiaoyan Wang, David R. Brown
Pages: 17 - 35
Number of pages: 19
Current Topics in Biochemical Research
Volume 12  Issue 1

Copyright © 2010 Research Trends. All rights reserved

ABSTRACT
 
α-synuclein is a protein of unknown function that aggregates in diseases such as Parkinson`s disease. The amyloidogenic nature of this protein has been implicated in disease and determine and regulating this process is important. Recent studies have suggested that copper or iron might bind to α-synuclein. Given the homology between the known synuclein proteins this opens up the possibility that they are a family of metal binding proteins. In this review we examine the evidence that synucleins bind metal and discuss the known implications of this.
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