Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 13  Issue 1
Targeting adenosine receptors for the treatment of cancers
Sarvesh Jajoo, Sandeep Sheth, Debashree Mukherjea, Tejbeer Kaur, Leonard P. Rybak, Vickram Ramkumar
Pages: 71 - 83
Number of pages: 13
Current Topics in Biochemical Research
Volume 13  Issue 1

Copyright © 2011 Research Trends. All rights reserved

Adenosine, produced from the metabolism of adenosine triphosphate (ATP), mediates a number of physiological actions by targeting G protein-coupled receptors, termed adenosine receptors (ARs). Four distinct types of these receptors, namely the A1, A2A, A2B and A3AR, have been identified and cloned, each of which shows distinct tissue distribution and function. A number of these receptors are targeted by caffeine and theophylline, ingredients in coffee and tea, which block the effects of endogenous adenosine at these receptor sites and provide the stimulant properties of these beverages. In recent years, a number of laboratories have been studying the role of these receptors in cancers. A number of studies have demonstrated that activation of ARs can either increase or decrease cancer cell proliferation and metastasis. This review will provide evidence implicating ARs in regulating cancer cell growth and proliferation and show how agonists or antagonists for these receptors could mediate anti-cancer responses. The cell signaling pathways mediating the differential responses to activation of AR subtypes will also be discussed.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms