ABSTRACT The complex process of bone matrix mineralization is tightly regulated by several transcription factors and signal transduction pathways. However, signal transduction pathways occur at protein level that depends not only on mRNA transcriptional regulation but also on a multitude of translational and posttranslational controls. Furthermore, proteomics allows a holistic view of complex molecular pathways and provides an efficient method to determine protein candidates and elucidate the signaling transduction pathways that regulate bone matrix mineralization.
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