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Current Topics in Pharmacology   Volumes    Volume 15  Issue 1
Role of proteinase-activated receptors in modulating nociceptive transmission to the spinal dorsal horn from the periphery
Tsugumi Fujita, Eiichi Kumamoto
Pages: 27 - 38
Number of pages: 12
Current Topics in Pharmacology
Volume 15  Issue 1

Copyright © 2011 Research Trends. All rights reserved

Nociceptive stimuli given to the periphery produce action potentials in the peripheral terminals of primary-afferent fibers and these electrical activities are transmitted through primary-afferent fibers to the spinal dorsal horn. Such nociceptive transmission is modulated by the actions of various receptors expressed in the peripheral and central terminals of primary-afferent fibers and in the spinal dorsal horn. Among the receptors, there are proteinase-activated receptors (PARs) which have a unique activation mechanism in that a proteolytically-exposed N-terminal region acts as a tethered ligand. This ligand binds to a site on the receptor itself, which results in triggering a signal transduction cascade. This review article will mention how the activation of the PARs modulates nociceptive transmission in the spinal dorsal horn.
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