An approach to the synthesis of phospholipid conjugates bearing both a polyunsaturated fatty acyl group and maltose or a flavonoid glycoside was studied. Under our established conditions, a linoleoyl-phosphatidyl derivative of naringin, a natural sugar flavonoid found in the inner peel of citrus fruits, as well as linoleoyl, icosapentaenoyl- or docosahexaenoyl-phosphatidyl derivatives of maltose could be synthesized via phospholipase D-catalyzed transphosphatidylation at 50 °C in chloroform.