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Current Topics in Pharmacology   Volumes    Volume 17  Issue 1
Abstract
The influence of sufan on myocardial energetic metabolism in the case of adriamycin-induced heart failure
Iryna Nizhenkovskaya
Pages: 103 - 108
Number of pages: 6
Current Topics in Pharmacology
Volume 17  Issue 1

Copyright © 2013 Research Trends. All rights reserved

ABSTRACT
 
The results of influence of the new non-glycoside structure metabolic cardiotonic drug sufan on the energetic metabolism and oxidative homeostasis indicators in myocardium, brain and spleen of intact rats and rats with adriamycin-induced heart failure are presented. This study shows that sufan increases the coefficient of oxidative/reductive forms of nicotinamide coenzymes and reduces the adriamycin caused deterioration of the energetic metabolism and the pro-oxidative-anti-oxidative homeostasis. It is suggested that the use of the non-glycoside structure cardiotonic drug sufan can be recommended for the prevention of cardiotoxic effects of the anthracycline antibiotics.
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