The results of influence of the new non-glycoside structure metabolic cardiotonic drug sufan on the energetic metabolism and oxidative homeostasis indicators in myocardium, brain and spleen of intact rats and rats with adriamycin-induced heart failure are presented. This study shows that sufan increases the coefficient of oxidative/reductive forms of nicotinamide coenzymes and reduces the adriamycin caused deterioration of the energetic metabolism and the pro-oxidative-anti-oxidative homeostasis. It is suggested that the use of the non-glycoside structure cardiotonic drug sufan can be recommended for the prevention of cardiotoxic effects of the anthracycline antibiotics.