Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Pharmacology   Volumes    Volume 7  Issue 1
Abstract
Receptor-interacting protein 140 as a negative coregulator of gene expression
Peter J. Franco, Xinli Hu, Li-Na Wei
Pages: 101 - 108
Number of pages: 8
Current Topics in Pharmacology
Volume 7  Issue 1

Copyright © 2003 Research Trends. All rights reserved

ABSTRACT

Receptor-interacting protein 140 (RIP140) has been shown to modulate gene expression directed by a variety of transcription factors from the nuclear receptor superfamily.  Nine copies of the “LXXLL” receptor-interacting motif and a recently identified novel ligand-dependent receptor-interacting motif in the carboxyl terminus of the protein direct binding of RIP140 to nuclear receptors.  The effect of RIP140 on gene expression depends on its ability to interact with a variety of nuclear factors involved in transcription.  In most cases, RIP140 acts as a negative coregulator causing a suppression of transcription.  This negative regulation is attributed to its ability to recruit histone deacetylases (HDACs) to transcription factor-occupied promoters.  This review discusses recent studies addressing the biological activity of RIP140 as a ligand-dependent negative coregulator for nuclear receptors.

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms