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Current Topics in Pharmacology   Volumes    Volume 7  Issue 1
Spontaneous rhythmic contraction of urinary bladder smooth muscle: pharmacological characteristics and its correlation with action potential generation
Yoshio Tanaka, Katsuo Koike
Pages: 117 - 124
Number of pages: 8
Current Topics in Pharmacology
Volume 7  Issue 1

Copyright © 2003 Research Trends. All rights reserved


Urinary bladder smooth muscle (UBSM) exhibits spontaneous contraction.  This spontaneous mechanical activity has been suggested to be closely related to the action potential generated in this smooth muscle cell to enhance Ca2+ influx through voltage-gated L-type Ca2+ channels.  In guinea-pig UBSM, both action potential and rhythmic mechanical contraction occur spontaneously in the presence of atropine, phentolamin, propranolol, suramin and tetrodotoxin, which suggests that both phenomena are myogenic in origin.  Although nisoldipine and diltiazem completely eliminate action potential generation, they inhibit only partly spontaneous mechanical activity.  On the other hand, iberiotoxin, a selective BK channel blocker, increases action potential frequency and UBSM contraction amplitude and its frequency.  Unexpectedly, but interestingly, 2-aminoethoxydiphenyl borate (2-APB) causes apparent dissociation between membrane electrical and mechanical activity in this guinea-pig smooth muscle.  Elevation of intracellular Ca2+ concentrations during a burst of action potentials can be significantly reflected as the changes in spontaneous mechanical activity in UBSM.  However, action potential does not seem to be the exclusive trigger mechanism to determine the generation of UBSM spontaneous mechanical activity.

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