Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Pharmacology   Volumes    Volume 7  Issue 1
Abstract
Dopamine transporter and neurodegeneration
Rumiko Kurosaki, Tsutomu Araki
Pages: 125 - 132
Number of pages: 8
Current Topics in Pharmacology
Volume 7  Issue 1

Copyright © 2003 Research Trends. All rights reserved

ABSTRACT

In several species including human, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces clinical, biochemical and neuropathological changes similar to those, which occur in Parkinson’s disease.  The dopamine transporter (DAT) is important to MPTP neurotoxicity because to be neurotoxin, an MPTP metabolite must first gain access to the dopaminergic neurons via DAT. Recent much evidence suggest that DAT is a mandatory factor for expression of MPTP neurotoxicity and may explain the selective neuronal damage in the substantia nigra against MPTP toxicity.  In view of new insights, this article demonstrates that DAT plays an important role in the MPTP neurotoxic process and specific blockade of DAT with high-affinity inhibitors in neurodegenerative diseases such as Parkinson’s disease, where the effective levels of dopamine are marked reduced, may have beneficial consequences.  Thus this review may provide valuable information for progressive neurodegeneration of the nigrostriatal dopaminergic neuronal pathway.

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms