Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 8  Issue 1
Mechanism of the production of reactive oxygen and nitrogen species in the stomach; their possible interaction with the cellular components related to gastric carcinogenesis
Tomiko Mikuni, Hiromu Nakajima, Manabu Ehara, Masaharu Tatsuta
Pages: 67 - 77
Number of pages: 11
Current Topics in Pharmacology
Volume 8  Issue 1

Copyright © 2004 Research Trends. All rights reserved


During the last two decades etiological studies have revealed that gastric cancer is associated with Helicobacter pylori (H. pylori) infection, cigarette smoking, unbalanced dietary habit, alcohol abuse, and pathophysiological stress. These conditions may be closely related to gastric cancer through the production of reactive oxygen species (ROS) such as hydroxyl free radical, and reactive nitrogen species (RNS) such as nitric oxide. Moreover a potent chemical gastric carcinogen, 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), is responsible for the carcinogenesis via formation of ROS and RNS.  In this review we show some evidence from which a theory that ROS and RNS can be potent carcinogens for gastric mucosa is derived.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms