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Current Topics in Pharmacology   Volumes    Volume 9  Issue 1
Mechanism of respiratory excitation by carbonic anhydrase inhibitor in rabbits
Kazuhisa Oogushi, Hiroaki Seino, Hiroyoshi Kawaai, Shinya Yamazaki, Kenji Taki
Pages: 109 - 115
Number of pages: 7
Current Topics in Pharmacology
Volume 9  Issue 1

Copyright © 2005 Research Trends. All rights reserved

This study assessed the mechanisms of respiratory centre excitation after administration of acetazolamide (AZ) as a carbonic anhydrase inhibitor (CAI) to rabbits. Male Japanese white rabbits were divided into group AZ5 (n=14, AZ 5 mg/kg) and group AZ20 (n=10, AZ 20 mg/kg). Each rabbit was anesthetized using ketamine and urethane under spontaneous respiration. Followed by inserting central venous and arterial catheters, a small catheter was inserted through an endotracheal tube for measuring end-tidal PCO2 (PetCO2), and a sigmoid tonometry catheter was inserted into the stomach through the oesophagus for measuring PCO2 in tissue. A percutaneous tissue CO2 sensor was embedded under the abdominal skin. Systolic arterial pressure (SAP), heart rate (HR), respiratory rate (RR), rectal temperature (RT), PetCO2, tissue CO2 pressure by gastric tonometry (PgtCO2), and CO2 pressure through percutaneous tissue (PptCO2), in arterial blood (PaCO2), and in mixed venous blood (PCO2) were measured for 180 min after AZ administration. In both groups, PetCO2 decreased significantly and RR, PgtCO2 and PptCO2 increased significantly in a dose-dependent manner after AZ administration. No other values showed significant changes. These results suggest that the respiratory centre might be stimulated by retained CO2 following CAI administration, with subsequent reduction of PetCO2 and significantly decreases in PaCO2 and PCO2. Therefore, attention should be paid to both increasing RR and retained CO2. PCO2 (PetCO2, PaCO2, PCO2, PgtCO2 and PptCO2) might thus warrant observation in severely ill patients while CAI is administered.
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