Metabolic syndrome is characterized to possess several abnormal syndrome, in one individual. The syndrome, including glucose intolerance, hyperinsulinemia, increased VLDL triglyceride, decreased HDL cholesterol, and hypertension, increase the risk of coronary artery disease. Recently, in western countries, the patient with metabolic syndrome is increasing, and insulin-resistance is regarded as a basic factor to develop the syndrome. Magnesium is an essential component of the body and plays crucial roles in many physiological functions and supplementation of magnesium has been reported to improve insulin-resistance. Deficiency of magnesium is not uncommon and there is a tight relation between low serum magnesium level and incidence of metabolic syndrome. Thus, improvement of insulin-resistance by magnesium supplementation is plausible way to prevent the development of metabolic syndrome with fewer side effects.
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