ABSTRACT The interaction of the two neuro-hypophyseal hormones oxytocin and lysine-vasopressin with the transport human serum albumin protein was investigated by measuring selective and double selective proton relaxation rates. The two peptides were shown to interact with the protein in the same mode but with different binding constants. Suche difference was ascribed to a diverse conformational situation of the two peptides in the free state in water solution. The same NMR measurements were used to provide evidence that calcium ions exert positive effects on the peptide-protein interactions.
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