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Current Topics in Pharmacology   Volumes    Volume 10  Issue 2
Use of antisense oligodeoxynucleotides for decreasing renal ischemia-reperfusion injury
Masahide Matsuyama, Rikio Yoshimura
Pages: 23 - 30
Number of pages: 8
Current Topics in Pharmacology
Volume 10  Issue 2

Copyright © 2006 Research Trends. All rights reserved

Renal ischemia-reperfusion (I/R) injury is a clinically significant problem and an invariable consequence of renal transplantation. The problem begins at the onset of acute tubular necrosis (ATN), when the transplantation takes a long ischemic interval by using the cardiac arrest donor`s kidney. In addition, the longer the ischemic interval, the higher the incidence rate of ATN. It is clinically important that renal I/R injury is reduced. The antisense oligodeoxynucleotide (AS-ODN), developed as a therapy for intractable diseases at the gene level, has recently been established as an important method in examining specific gene functions. The authors have previously demonstrated that AS-ODN/tissue factor (TF) prevents renal I/R injury. This review discusses the efficacy of AS-ODN/TF and AS-ODN/intercellular adhesion molecule-1 as existing targets, and the potential of AS-ODN/nuclear factor-kappaB, AS-ODN/cyclooxygenase and AS-ODN/5-lipoxygenase as prospective targets.
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