Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Biochemical Research   Volumes    Volume 11  Issue 2
Abstract
Glucose metabolism, transcriptional regulation, and angiogenesis
David R. D’Souza, Adam Pierce, Geoffrey Girnun, Antonino Passaniti
Pages: 41 - 55
Number of pages: 15
Current Topics in Biochemical Research
Volume 11  Issue 2

Copyright © 2009 Research Trends. All rights reserved

ABSTRACT
 
Angiogenesis promotes tumor growth and metastasis. Current paradigms that attempt to define its contribution to tumorigenesis include the concept of the angiogenic switch and the role of circulating endothelial progenitor cells. Specific metabolic signaling pathways that respond to oxygen and nutrients in the tumor microenvironment are also critical effectors of the angiogenic response. These pathways may be exploited for therapeutic benefit to deliver agents at the appropriate dose and time (metronomic therapy), to promote vessel normalization and prevent vascular expansion, and to improve drug delivery and reduce drug resistance. The angiogenic switch is associated with loss of tumor dormancy and is regulated by transcription factors that activate specific target genes. These transcription factors and transcriptional activators/ repressors respond to nutrients and oxygen to regulate the vascular endothelial cell phenotype. Glucose metabolism and specific signaling pathways regulate the expression of several angiogenic and anti-angiogenic transcription factors including p53, Id, PPAR, Hif1α, c-myc, Foxo, and RUNX2 as well as several cofactors such as PGC1α and SIRT. Conversely, these transcriptional regulators also alter the overall signaling pathways in activated endothelial cells and modify the metabolic state of vascular cells. This review will focus on how the RUNX2 and PGC1α transcriptional regulators respond to nutrients such as glucose and how they affect the metabolic state of endothelial cells. The feasibility of using these transcription factors as markers of the angiogenic phenotype and as targets for chemoprevention and/or treatment is discussed.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms