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Current Topics in Pharmacology   Volumes    Volume 15  Issue 2
Abstract
Electropharmacological properties of the pulmonary vein myocardium
Hikaru Tanaka, Yayoi Tsuneoka, Iyuki Namekata
Pages: 19 - 24
Number of pages: 6
Current Topics in Pharmacology
Volume 15  Issue 2

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
The pulmonary vein myocardium is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis in various experimental animal species have revealed the characteristics of the pulmonary vein myocardium such as lower repolarizing capacity and presence of intracellular Ca2+ oscillations. Pulmonary vein automaticity is affected by various neurohumoral substances and pharmacological agents. Studies on the mechanisms and regulation of pulmonary vein automaticity would lead to the development of novel therapeutic strategies for atrial fibrillation.
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