Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 7  Issue 2
Interaction of serotonin receptors on the raphe nuclei
Claire Roberts
Pages: 263 - 267
Number of pages: 5
Current Topics in Pharmacology
Volume 7  Issue 2

Copyright © 2003 Research Trends. All rights reserved


The majority of 5-HT fibres originate from the dorsal and median raphe nuclei: DRN and MRN repectively, where 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A and 5-HT7 receptors have been localised in the raphe. Selective receptor antagonists are available to investigate the function of these receptors, except for 5-HT5A where we still await the discovery of selective compounds.

In the DRN, 5-HT1A receptors play an important role in regulating 5-HT release. Both 5-HT1B and 5-HT7 receptor antagonists have little effect on 5-HT release per se but increase 5-HT release in the presence of 5-HT1A receptor blockade. In contrast, 5-HT1D receptor antagonists increase 5-HT release per se and are not affected by 5-HT1A receptor blockade. In the MRN, 5-HT1B receptors are thought to play a more dominant function in regulating 5-HT release. 5-HT1B receptor blockade increases 5-HT release per se which is not modulated by 5-HT1A receptor antagonism.

Therefore, to achieve maximum elevation of 5-HT release in the raphe nuclei one would need either a combination 5-HT1A and 5-HT1B or 5-HT1A and 5-HT7 receptor blockade. However, we await the emergence of selective 5-HT5A compounds to assess the functional importance of this receptor in the raphe.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms