Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Phytochemistry   Volumes    Volume 1 
Recent advances in quinone biosynthesis and related gene expression in Lithospermum erythrorhizon
Kazufumi Yazaki
Pages: 125 - 135
Number of pages: 11
Current Topics in Phytochemistry
Volume 1 

Copyright © 1997 Research Trends. All rights reserved

Cell suspension cultures of Lithospermum erythrorhizon are capable of producing a large amount of shikonin derivatives (red naphthoquinone pigments specific to the roots) when transferred to pigment production medium M9, although the pigment production fails in Linsmaier and Skoog’s (LS) liquid medium used for subculture. Shikonin is biosynthesized by coupling of p-hydroxybenzoic acid (PHB) derived from shikimate pathway, and geranyldiphosphate from mevalonate pathway. We have been studying the regulatory mechanism of shikonin biosynthesis on chemical and biochemical level, as well as molecular genetic level. In this paper, regulation of PHB accumulation, one of the key intermediate of shikonin biosynthesis, and gene expression of two enzymes, phenylalanine ammonia-lyase and 4-couma-rate: CoA ligase, involved in the biosynthetic pathway of shikonin are elucidated. In recent years, it was also found that Lithospermum cell cultures synthesize benzoquinone derivatives, and phenylpropanoids as end products, adding shikonin. The biosynthetic regulation of the branching point between shikonin and benzofurans is also discussed.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms