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Current Topics in Analytical Chemistry   Volumes    Volume 3 
Abstract
Aptamers (nucleic acid ligands) for trypsin-like serine proteases: finding the enzyme's Achilles heel
Satoshi Nishikawa, Joonsung Hwang, Hamid Fauzi, Kotaro Fukuda, Fumiko Nishikawa, Nobuko Kakiuchi
Pages: 69 - 81
Number of pages: 13
Current Topics in Analytical Chemistry
Volume 3 

Copyright © 2002 Research Trends. All rights reserved

ABSTRACT

Since the development of in vitro selection, more than 50 nucleic acid ligands (aptamers) have been isolated. These molecules are very useful for studying molecular recognition between nucleic acid and protein/organic compounds. In vitro selection also possesses the potential to enable us to produce new drugs for the fight against disease. We focused on several aptamers that specifically bind to trypsin-like serine proteases (thrombin, human neutrophil elastase, activated protein C, and NS3 protease of human hepatitis C virus) and introduce their interactions. These aptamers interact at exosites of proteases and inhibit their function - exposing the enzyme`s Achilles heel.

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