Individual and simultaneous quantitative high performance thin layer chromatography (HPTLC)-densitometry methods for lumefantrine and artemether in a combined tablet formulation were developed by transfer of qualitative screening methods contained in the Global Pharma Health Fund E. V. Minilab manual using a model procedure published earlier including sample and standard solution preparation, calibration curve establishment, assay of pharmaceutical products versus the label values, and validation of precision, accuracy, and sample peak purity and identification. The new methods involve use of inexpensive, relatively nontoxic and readily available “green” mobile phase solvents specified for Minilab methods, EMD Millipore Corp. Premium Purity HPTLC silica gel 60 F₂₅₄ glass plates, automated standard and sample solution application with a CAMAG Linomat 4, and automated densitometry for detection, identification, and quantification with a CAMAG Scanner 3. Direct transfer of individual Minilab methods for the two individual drugs as well as modifications made in developing the simultaneous method are reported. To our knowledge, no previous quantitative HPTLC simultaneous method using the Minilab mobile phases and our reagent free thermochemical activation detection method for artemether has been reported for a combined dosage form with lumefantrine.