ABSTRACT A new approach to photoprotection is to reverse the biological consequences of UV after sun exposure by enhancing DNA repair. Liposomes encapsulating biologically active proteins for repair of DNA damage were prepared, including photolyase liposomes containing the photoreactivating enzyme from A. nidulans, and T4N5 liposomes containing the excision repair enzyme T4 endonuclease V. The effect of these liposomes on DNA repair and other biological endpoints in UV irradiated cells and mouse and human skin models are reviewed. The photorepair liposomes have the potential to complement the use of sunscreens in preventing and reversing actinic changes from UV exposure.
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